W.H. Wilson Tang and Stanley L. Hazen, from the Department of Cellular and Molecular Medicine, Lerner Research Institute, and Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio, USA, recently discovered that certain dietary nutrients possessing a trimethylamine (TMA) moiety, namely choline/ phosphatidylcholine and L-carnitine, participate in the development of atherosclerotic heart disease. This studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.
- Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
- A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects
- ‘Multi-kingdom dialogue’ between internal, external microbiota
- Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling
- Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis