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Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

by Igen BioLab Group | Jul 19, 2021 | News, Publications

Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB...
Differences in the bacteriome of swab, saliva, and tissue biopsies in oral cancer

Differences in the bacteriome of swab, saliva, and tissue biopsies in oral cancer

by Igen BioLab Group | Jan 22, 2021 | News, Publications

Microbial dysbiosis has been implicated in the pathogenesis of oral cancer. We analyzed the compositional and metabolic profile of the bacteriome in three specific niches in oral cancer patients along with controls using 16SrRNA sequencing (Illumina Miseq) and DADA2...
The Lung Microbiome May Affect Lung Cancer Pathogenesis and Prognosis

The Lung Microbiome May Affect Lung Cancer Pathogenesis and Prognosis

by Igen BioLab Group | Nov 12, 2020 | News, Publications

Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association...
Cancer and the gut microbiota: An unexpected link

Cancer and the gut microbiota: An unexpected link

by Igen BioLab Group | Aug 31, 2020 | News, Publications

Accumulating evidence demonstrates that intestinal bacteria influence oncogenesis, tumor progression, and response to therapy. Thus, selectively manipulating the gut microbiota may represent a feasible means to limit the incidence of specific tumors in the general...

Recent Posts

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  • Intestinal microbiota drive CRPC
  • Hormone-producing bacteria drive prostate cancer
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