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Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis

Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis

by Igen BioLab Group | Nov 22, 2021 | Publications

Gut dysbiosis is observed in chronic hepatobiliary diseases and is frequently associated with liver carcinogenesis; however, the extent and specific mechanisms triggered by alterations in the microbiota mediating tumorigenesis in these patients remain unclear. Here we...
Gut Bacteria may Fuel prostate Cancer Treatment Resistance

Gut Bacteria may Fuel prostate Cancer Treatment Resistance

by Igen BioLab Group | Oct 25, 2021 | Publications

A mainstay of treatment for prostate cancer is to deprive it of androgens, the hormones that make it grow. The testes are the main source of these hormones, so treatment can consist of either surgical removal of these organs or use of drugs to block...
Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

by Igen BioLab Group | Sep 1, 2020 | Publications

The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes without killing the commensal bacteria essential...

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