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Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

by Igen BioLab Group | Sep 1, 2020 | News, Publications

The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial β-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes without killing the commensal bacteria essential...

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