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Human and preclinical studies of the host–gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health

Human and preclinical studies of the host–gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health

by Igen BioLab Group | May 26, 2021 | News, Publications

Objective Gut microbial products are involved in regulation of host metabolism. In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of metabolic...
Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Gut microbiome pattern reflects healthy ageing and predicts survival in humans

by Igen BioLab Group | Feb 25, 2021 | News, Publications

The gut microbiome has important effects on human health, yet its importance in human ageing remains unclear. In the present study, we demonstrate that, starting in mid-to-late adulthood, gut microbiomes become increasingly unique to individuals with age.  We leverage...
Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

by Igen BioLab Group | Jan 21, 2021 | News, Publications

The gut microbiome can influence the development of tumors and the efficacy of cancer therapeutics; however, the multiomics characteristics of antitumor bacterial strains have not been fully elucidated. In this study, we integrated metagenomics, genomics and...
Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

Infants born to mothers with IBD present with altered gut microbiome that transfers abnormalities of the adaptive immune system to germ-free mice

by Igen BioLab Group | Aug 10, 2020 | News, Publications

Prenatal and early life bacterial colonisation is thought to play a major role in shaping the immune system. Furthermore, accumulating evidence links early life exposures to the risk of developing IBD later in life. We aimed to assess the effect of maternal IBD on the...

Recent Posts

  • Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
  • A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects
  • ‘Multi-kingdom dialogue’ between internal, external microbiota
  • Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling
  • Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis
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