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Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

by Igen BioLab Group | Mar 3, 2022 | News, Publications

Previous studies have suggested that the gut microbiome influences the response to checkpoint inhibitors (CPIs) in patients with cancer. CBM588 is a bifidogenic live bacterial product that we postulated could augment CPI response through modulation of the gut...
Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

by Igen BioLab Group | Mar 3, 2022 | News, Publications

Ample evidence indicates that the gut microbiome is a tumor-extrinsic factor associated with antitumor response to anti-programmed cell death protein-1 (PD-1) therapy, but inconsistencies exist between published microbial signatures associated with clinical outcomes....
Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy

Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy

by Igen BioLab Group | Feb 10, 2022 | News, Publications

Research on the relationship between microbiome and cancer has made significant progress in the past few decades. It is now known that the gut microbiome has multiple effects on tumour biology. However, the relationship between intratumoral bacteria and cancers...
Mechanisms underlying interactions between two abundant oral commensal bacteria

Mechanisms underlying interactions between two abundant oral commensal bacteria

by Igen BioLab Group | Nov 11, 2021 | Publications

Complex polymicrobial biofilm communities are abundant in nature particularly in the human oral cavity where their composition and fitness can affect health. While the study of these communities during disease is essential and prevalent, little is known about...
10th Microbiome Interactions in Health and Disease meeting

10th Microbiome Interactions in Health and Disease meeting

by Igen BioLab Group | Oct 14, 2021 | Events

The 10th Microbiome Interactions in Health and Disease meeting will once again bring together leading scientists and clinicians from the fields of microbiology, gastroenterology, neuroscience and public health to discuss the latest developments in this fast-moving...
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Recent Posts

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  • Microbiota and Cancer: The Emerging Beneficial Role of Bifidobacteria in Cancer Immunotherapy
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