Publications
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Several species of intestinal bacteria have been associated with enhanced efficacy of checkpoint blockade immunotherapy, but the underlying mechanisms by which the microbiome enhances antitumor immunity are unclear. bacteria Several species of intestinal bacteria have...
Oral Microbiota and Cancer Development
Oral microbiota are among the most diverse in the human body. More than 700 species have been identified in the mouth, and new sequencing methods are allowing us to discover even more species. The anatomy of the oral cavity is different from that of other body sites....
Bugs as Drugs: The Role of Microbiome in Cancer Focusing on Immunotherapeutics
The human microbiome comprising microorganisms, their collective genomes and metabolic products has gained tremendous research interest in oncology, as multiple cohorts and case studies have demonstrated discernible interpatient differences in this ecosystem based on...
The Lung Microbiome May Affect Lung Cancer Pathogenesis and Prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association...
Identifying gut microbes that affect human health
The resident microorganisms in the human body, termed the microbiota, represent diverse communities of microbial species comprising a complex ecology of tens of trillions of mainly bacterial cells. Our gut microbiota, the largest and most diverse of these communities,...
A trial of one of Igen Biolab Group’s products to investigate Age-Related Macular Degeneration (AMD) is approved
Javier Asarta, CEO of the Igen Biolab Group: “AMD affects some 700,000 people in Spain and currently has no treatment”.Dr Jordi Monés, study author: “As well as the medical benefits for patients, it reduces the socio-economic burden by preventing or improving the...
Emerging roles of the microbiome in cancer
Gene-environment interactions underlie cancer susceptibility and progression. Yet, we still have limited knowledge of which environmental factors are important and how they function during tumorigenesis. In this respect, the microbial communities that inhabit our...
The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: Implications for clinical outcomes
From digestion to pathogen resistance and immune system development, the gut microbiota and its collection of microbial genes are redefining what it means to be human. Despite tremendous advances in this field, there is still a limited understanding of how microbial...
Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals
Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as most studies have employed sequencing technologies to investigate faecal microbiota only. This work used...