News
UF Health Cancer Center expands research programs to enhance discoveries
The University of Florida Health Cancer Center has expanded its research programs to strengthen the impact of cancer research and meet the needs of an expanding membership. The expansion will make it easier and faster for investigators to directly apply their...
Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index
Colorectal Cancer (CRC) and Obesity constitute two of the most common malignancies in the western world, and previously have been associated with intestinal microbial composition alterations. Our main aim in this study is to provide molecular data on intestinal...
Targeting Microbiota 2023 captures the essence of microbiota research and future implications
Diversity of Topics: The talks span a wide range of topics, from specific diseases to broader environmental and anthropological considerations. Health & Disease Focus: A significant portion of the talks delve into the link between microbiota and various diseases,...
Press Releases
Abstract 651: Revealing the role of lung cancer microbiota in the tumor progression
Lung cancer (LC) remains as the leading cause of death by cancer worldwide. In Chile, LC is the second cause of cancer-related deaths. Recently, studies in melanoma and non-small cell lung cancer (NSCLC) patients have highlighted the role of the gut microbiota as an...
How the gut microbiome can help predict cancer immunotherapies
Transatlantic research group uncovers possible link between gut microbiota and cancer immunotherapy efficacy An international team of experts headed by Prof. Dr. Eran Elinav of the Cancer & Microbiome Division of the German Cancer Research Center (DKFZ), and led...
Intratumoral microbiome is driven by metastatic site and associated with immune histopathological parameters: An ancillary study of the SHIVA clinical trial
Sixteen percent of cancers worldwide are attributable, at least in part, to infection, showing the link between microbial agents and tumorigenesis [1]. Studies to further investigate the role of the microbiome in cancer have accumulated in recent years, with a...
Events
Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma
Characterization of the oral microbiota profile through various studies has shown an association between the microbiome and oral cancer; however, stage-specific determinants of dynamic changes in microbial communities of oral cancer remain elusive. Additionally, the...
Elucidating colorectal cancer-associated bacteria through profiling of minimally perturbed tissue-associated microbiota
Sequencing-based interrogation of gut microbiota is a valuable approach for detecting microbes associated with colorectal cancer (CRC); however, such studies are often confounded by the effect of bowel preparation. In this study, we evaluated the viability of...
Intratumor microbiota: a novel tumor component
Bacteria have been found in tumors for over 100 years, but the irreproducibility of experiments on bacteria, the limitations of science and technology, and the contamination of the host environment have severely hampered most research into the role of bacteria in...
Publications
Interplay Between Oncomicrobes, the Microbiota and the Immune System: Impact on Responses to Cancer Immunotherapy
Cancer immunotherapies harness the power of the immune system to target cancer cells that express tumor-associated antigens. Immune checkpoint inhibitors, such as monoclonal antibodies against inhibitory T cell receptors, i.e., PD-1/PD-L1 and CTLA-4, allow cancer...
Combined Microbiome and Metabolome Analysis Reveals a Novel Interplay Between Intestinal Flora and Serum Metabolites in Lung Cancer
As the leading cause of cancer death, lung cancer seriously endangers human health and quality of life. Although many studies have reported the intestinal microbial composition of lung cancer, little is known about the interplay between intestinal microbiome and...
Alterations of lung microbiota in patients with non-small cell lung cancer
The role of lung microbiota in non-small cell lung cancer remains unclear. We investigated the characteristics and functional roles of lung microbiota in non-small cell lung cancer.Bronchoalveolar lavage fluid samples were obtained from patients with non-small cell...