The microbiome and human cancer
BACKGROUND: Historical accounts linking cancer and microbes date as early as four millennia ago. Post establishment of the germ theory of infectious diseases, clinical research of microbial influences on cancer began in 1868, when William Busch reported spontaneous...
The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?
The association between colorectal cancer (CRC) and alterations in intestinal microbiota has been demonstrated by several studies, and there is increasing evidence that bacteria are an important component of the tumour microenvironment. Bacteria may contribute to the...
Microbiome Interactions in Health and Disease
The 11th Microbiome Interactions in Health and Disease meeting will bring together leading scientists and clinicians from the fields of microbiology, gastroenterology, nutrition, cancer and public health to discuss the latest developments in this fast-moving area....
Unhealthy Gut Helps Breast Cancer Spread, Research Reveals
An unhealthy gut triggers changes in normal breast tissue that helps breast cancer spread to other parts of the body, new research from UVA Cancer Center reveals. The gut microbiome – the collection of microbes that naturally live inside us – can be disrupted by poor...
Research progress on the effect of gut and tumor microbiota on antitumor efficacy and adverse effects of chemotherapy drugs
Chemotherapy is one of the most effective methods of systemic cancer treatment. Chemotherapy drugs are delivered through the blood circulation system, and they can act at all stages of the cell cycle, and can target DNA, topoisomerase, or tubulin to prevent the growth...
New Insights Into the Cancer–Microbiome–Immune Axis: Decrypting a Decade of Discoveries
The past decade has witnessed groundbreaking advances in the field of microbiome research. An area where immense implications of the microbiome have been demonstrated is tumor biology. The microbiome affects tumor initiation and progression through direct effects on...
Human Microbiome and Cancer
The microbiome refers to the collection of all of the gene sequences from a community of microbes in the human body. High-throughput DNA amplification and sequencing technologies to characterize the microbial communities provide data for investigations of microbial...
The promise and challenge of cancer microbiome research
The human microbiome is a significant community, with an estimated ratio of one microbial cell per human cell [1] and nearly 500-fold more microbial genes than host genes [2]. This community is dynamically shaped alongside human development from birth through...
