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Bugs as Drugs: The Role of Microbiome in Cancer Focusing on Immunotherapeutics
The human microbiome comprising microorganisms, their collective genomes and metabolic products has gained tremendous research interest in oncology, as multiple cohorts and case studies have demonstrated discernible interpatient differences in this ecosystem based on...
The Lung Microbiome May Affect Lung Cancer Pathogenesis and Prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association...
Identifying gut microbes that affect human health
The resident microorganisms in the human body, termed the microbiota, represent diverse communities of microbial species comprising a complex ecology of tens of trillions of mainly bacterial cells. Our gut microbiota, the largest and most diverse of these communities,...
A trial of one of Igen Biolab Group’s products to investigate Age-Related Macular Degeneration (AMD) is approved
Javier Asarta, CEO of the Igen Biolab Group: “AMD affects some 700,000 people in Spain and currently has no treatment”.Dr Jordi Monés, study author: “As well as the medical benefits for patients, it reduces the socio-economic burden by preventing or improving the...
Emerging roles of the microbiome in cancer
Gene-environment interactions underlie cancer susceptibility and progression. Yet, we still have limited knowledge of which environmental factors are important and how they function during tumorigenesis. In this respect, the microbial communities that inhabit our...
The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: Implications for clinical outcomes
From digestion to pathogen resistance and immune system development, the gut microbiota and its collection of microbial genes are redefining what it means to be human. Despite tremendous advances in this field, there is still a limited understanding of how microbial...
Compositional and functional differences of the mucosal microbiota along the intestine of healthy individuals
Gut mucosal microbes evolved closest to the host, developing specialized local communities. There is, however, insufficient knowledge of these communities as most studies have employed sequencing technologies to investigate faecal microbiota only. This work used...
The Role of the Microbiome in Cancer and Therapy Efficacy: Focus on Lung Cancer
The microbiome is extremely important for human health; more recently its role in the context of cancer became clear. Microbial effects range from enhancing cancer immunity and cancer therapy efficacy, to promoting cancer progression and inhibiting treatment efficacy....
Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians
Exceptionally long-lived people such as supercentenarians tend to spend their entire lives in good health, implying that their immune system remains active to protect against infections and tumors. However, their immunological condition has been largely unexplored. We...