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Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment
The human gut is a host for trillions of microorganisms, divided into more than 3,000 heterogeneous species that is called the gut microbiota. The gut microbiota composition can be altered by many different endogenous and exogenous factors, especially diet and...
Gut microbiome immaturity and childhood acute lymphoblastic leukaemia
Acute lymphoblastic leukaemia (ALL) accounts for one-third of paediatric cancer cases in developed societies1. Although treatment of paediatric ALL is highly successful with cure rates of around 90%2, the longer-term complications of therapy and impact on quality of...
Microbiome therapies: a maturing movement
On World Microbiome Day 2023, Hervé Affagard, CEO and co-founder of MaaT Pharma and Jeffrey Silber, Chief Medical Officer of Vedanta Biosciences delve into the current innovative landscape of microbiome-based therapeutics. Riding on the momentum of the first faecal...
Live Biotherapeutic Products as Cancer Treatments
Almost every aspect of cancer can be influenced by microbiota including tumor onset, progression, and response to therapy. The increasing evidence of the role of microbiota in human health and disease has reinvigorated the interest in designing microbial products that...
NCI-funded project to study role of gut microbiome in prostate cancer
The study builds on their recent collaboration with the laboratory of Andrea Alimonti, M.D., head of molecular oncology at the Institute of Oncology Research in Switzerland, about the role of microbiota in castration-resistant prostate cancer. This type of prostate...
Gut microbiota in colorectal cancer development and therapy
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC is its intimate association with the gut microbiota, which forms an essential part of the tumour microenvironment. Research over the past decade has established that dysbiosis of...
The Barcelona Debates on the Human Microbiome 2023
The Barcelona Debates on the Human Microbiome is an annual conference that brings together leading researchers and experts to discuss the latest developments in microbiome research. The ninth edition of the congress, organised by IrsiCaixa, with the support of “la...
Study identifies how microbiome may affect pancreatic cancer outcomes
Research finds certain species elevated in long-term survivors Even as pancreatic cancer treatments improve, only about 9% of patients survive past five years. Researchers have searched unsuccessfully to find genetic differences that explain why some patients survive...
An integrated tumor, immune and microbiome atlas of colon cancer
The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, we performed comprehensive genomic analyses on fresh-frozen samples from 348 patients affected by...
