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UF Health Cancer Center expands research programs to enhance discoveries
The University of Florida Health Cancer Center has expanded its research programs to strengthen the impact of cancer research and meet the needs of an expanding membership. The expansion will make it easier and faster for investigators to directly apply their...
Gut microbiota profiles in feces and paired tumor and non-tumor tissues from Colorectal Cancer patients. Relationship to the Body Mass Index
Colorectal Cancer (CRC) and Obesity constitute two of the most common malignancies in the western world, and previously have been associated with intestinal microbial composition alterations. Our main aim in this study is to provide molecular data on intestinal...
Targeting Microbiota 2023 captures the essence of microbiota research and future implications
Diversity of Topics: The talks span a wide range of topics, from specific diseases to broader environmental and anthropological considerations. Health & Disease Focus: A significant portion of the talks delve into the link between microbiota and various diseases,...
Intratumoral Microbiota Changes with Tumor Stage and Influences the Immune Signature of Oral Squamous Cell Carcinoma
Characterization of the oral microbiota profile through various studies has shown an association between the microbiome and oral cancer; however, stage-specific determinants of dynamic changes in microbial communities of oral cancer remain elusive. Additionally, the...
Elucidating colorectal cancer-associated bacteria through profiling of minimally perturbed tissue-associated microbiota
Sequencing-based interrogation of gut microbiota is a valuable approach for detecting microbes associated with colorectal cancer (CRC); however, such studies are often confounded by the effect of bowel preparation. In this study, we evaluated the viability of...
Intratumor microbiota: a novel tumor component
Bacteria have been found in tumors for over 100 years, but the irreproducibility of experiments on bacteria, the limitations of science and technology, and the contamination of the host environment have severely hampered most research into the role of bacteria in...
Faecal microbiota composition is related to response to CDK4/6-inhibitors in metastatic breast cancer: A prospective cross-sectional exploratory study
Cyclin-dependent kinase (CDK)4/6-inhibitors with endocrine therapy represent the standard of treatment of hormone receptor-positive(HR+)/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Gut microbiota seems to predict treatment...
Chasing the Mysteries of Microbiome Communication in Our Bodies
When we hear about gut bacteria, we may think about probiotics and supplements marketed to help with digestion, about how taking antibiotics might affect our intestinal tract, or perhaps about trendy diets that aim to improve gut health. But two researchers at Penn...
Advances in the Microbiome, Immunity and Cancer interplay
Gut microbiome plays an important role in colorectal cancer (CRC) initiation, progression and response to different systemic therapies. On its turn, gut microbiome is influenced by host factors (race, sex, genetic predisposition, oxidative stress, metabolic and...