News
Elucidating colorectal cancer-associated bacteria through profiling of minimally perturbed tissue-associated microbiota
Sequencing-based interrogation of gut microbiota is a valuable approach for detecting microbes associated with colorectal cancer (CRC); however, such studies are often confounded by the effect of bowel preparation. In this study, we evaluated the viability of...
Intratumor microbiota: a novel tumor component
Bacteria have been found in tumors for over 100 years, but the irreproducibility of experiments on bacteria, the limitations of science and technology, and the contamination of the host environment have severely hampered most research into the role of bacteria in...
Faecal microbiota composition is related to response to CDK4/6-inhibitors in metastatic breast cancer: A prospective cross-sectional exploratory study
Cyclin-dependent kinase (CDK)4/6-inhibitors with endocrine therapy represent the standard of treatment of hormone receptor-positive(HR+)/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Gut microbiota seems to predict treatment...
Chasing the Mysteries of Microbiome Communication in Our Bodies
When we hear about gut bacteria, we may think about probiotics and supplements marketed to help with digestion, about how taking antibiotics might affect our intestinal tract, or perhaps about trendy diets that aim to improve gut health. But two researchers at Penn...
Advances in the Microbiome, Immunity and Cancer interplay
Gut microbiome plays an important role in colorectal cancer (CRC) initiation, progression and response to different systemic therapies. On its turn, gut microbiome is influenced by host factors (race, sex, genetic predisposition, oxidative stress, metabolic and...
Functional biotransformation of phytoestrogens by gut microbiota with impact on cancer treatment
The human gut is a host for trillions of microorganisms, divided into more than 3,000 heterogeneous species that is called the gut microbiota. The gut microbiota composition can be altered by many different endogenous and exogenous factors, especially diet and...
Gut microbiome immaturity and childhood acute lymphoblastic leukaemia
Acute lymphoblastic leukaemia (ALL) accounts for one-third of paediatric cancer cases in developed societies1. Although treatment of paediatric ALL is highly successful with cure rates of around 90%2, the longer-term complications of therapy and impact on quality of...
Microbiome therapies: a maturing movement
On World Microbiome Day 2023, Hervé Affagard, CEO and co-founder of MaaT Pharma and Jeffrey Silber, Chief Medical Officer of Vedanta Biosciences delve into the current innovative landscape of microbiome-based therapeutics. Riding on the momentum of the first faecal...
Live Biotherapeutic Products as Cancer Treatments
Almost every aspect of cancer can be influenced by microbiota including tumor onset, progression, and response to therapy. The increasing evidence of the role of microbiota in human health and disease has reinvigorated the interest in designing microbial products that...
