News
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events.
A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects
Administration of cultured gut isolates holds promise for modulating the altered composition and function of the microbiota in older subjects, and for promoting their health.
‘Multi-kingdom dialogue’ between internal, external microbiota
National Institutes of Health scientists and their collaborators have identified an internal communication network in mammals that may regulate tissue repair and inflammation.
Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling
Excessive intake of animal fat and resultant obesity are major risk factors for prostate cancer (PCa). Because the composition of the gut microbiota is known to change with dietary composition and body type, we used prostate-specific Pten knockout.
Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis
Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes.
Prevotella diversity, niches and interactions with the human host
The genus Prevotella includes more than 50 characterized species that occur in varied natural habitats, although most Prevotella spp. are associated with humans.
Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment
The prognosis of early breast cancer (BC) relies on cell autonomous and immune parameters. The impact of the intestinal microbiome on clinical outcome has not yet been evaluated
Human and preclinical studies of the host–gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health
In human and experimental studies, we explored the potential role of hippurate, a hepatic phase 2 conjugation product of microbial benzoate, as a marker and mediator of metabolic health.
Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms
The need for highly effective vaccines that induce robust and long-lasting immunity has never been more apparent.