News
Microbial link between Western-style diet and incidence of colorectal cancer uncovered
New research builds the case that a Western-style diet -- rich in red and processed meat, sugar and refined grains/carbohydrates -- is tied to higher risk of colorectal cancer through the intestinal microbiota. Investigators from Brigham and Women's Hospital with...
Intratumor microbiome in cancer progression: current developments, challenges and future trends
The human body comprises a mixture of mammalian and microbial cells, with the latter exceeding the former by nearly tenfold. The microbial genetic repertoire is approximately 100-fold more abundant than that of the human host. Beyond bacteria, the human commensal...
Facts and Hopes for Gut Microbiota Interventions in Cancer Immunotherapy
Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1) proteins transformed the management of advanced cancers. Many tumor-intrinsic factors modulate immunological and clinical responses to such...
Colorectal microbiota after removal of colorectal cancer
Colorectal cancer (CRC) remains one of the major causes of mortality. Hereditary cancers account for a minority of cases while environmental and lifestyle factors are the main driver of sporadic CRC. The pathogenesis of most cases of sporadic CRC is thought to involve...
Targeting the microbiome in patients with melanoma – ready for prime time?
VCCC Alliance Melanoma Symposium sponsored by Novartis A/Prof David Gyorki (VCCC Alliance Research & Education Lead for Melanoma and Skin Cancers) will be joined by a multidisciplinary panel of experts for an insightful look into the role the gut microbiome plays...
Interplay Between Gut Microbiota and the Host Immune System: What Do We Know and What Is on the Horizon?
Key Points Researchers have identified a connection between unfavorable gut bacteria and laboratory markers of inflammation in patients with non–small cell lung cancer, which in turn correlate with a poor response to immune checkpoint inhibitor therapy. Three phase 1...
Researchers are harnessing the microbiome to modulate treatment response
“You are what you eat” is more than a catchy aphorism. In cancer treatment response, it is the literal truth: Altering the composition of the gut microbiome can change response to some chemotherapy and immunotherapy regimens, and altering the tumor microbiome can have...
How diet and the microbiome affect colorectal cancer
UC research identifies microbial species elevated in young patients While recommended screenings beginning at age 45 have helped decrease colorectal cancer cases in older adults, cancer rates are continuing to increase in younger populations. Since 2009, the rate of...
Can the Gut Microbiome Predict Response to Cancer Treatment?
The gut has a big role to play in our susceptibility to having good health and how well we respond to various forms of medical treatment. Within the gut lies trillions of living microorganisms that make up the gut microbiota. The role that microorganisms play within...
