Microbiota contributions
Intratumoral microbiota have been described in various human cancers. In Nature, Bullman and colleagues use in situ spatial-profiling technologies and single-cell RNA sequencing (scRNA-seq) to map host–bacterial interactions within the tumour microenvironment. In oral...
Gastric Microbiome Alterations Are Associated with Decreased CD8+ Tissue-Resident Memory T Cells in the Tumor Microenvironment of Gastric Cancer
The host microbiota is closely associated with tumor initiation and progression in multiple solid tumors including gastric cancer. The aim of this study was to investigate in patients with gastric cancer whether there are alterations in gastric microbiota and any...
The microbiome and human cancer
BACKGROUND: Historical accounts linking cancer and microbes date as early as four millennia ago. Post establishment of the germ theory of infectious diseases, clinical research of microbial influences on cancer began in 1868, when William Busch reported spontaneous...
The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?
The association between colorectal cancer (CRC) and alterations in intestinal microbiota has been demonstrated by several studies, and there is increasing evidence that bacteria are an important component of the tumour microenvironment. Bacteria may contribute to the...
