A host’s microbiota may increase, diminish, or have no effect at all on cáncer susceptibility. Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host-microbiota interactions with environmental factors in carcinogenesis, and exploiting such knowledge for cancer diagnosis and treatment are areas of intensive interest. This Review considers how microbes and the microbiota may amplify or mitigate carcinogenesis, responsiveness to cancer therapeutics, and cancer-associated complications.
- Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
- A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects
- ‘Multi-kingdom dialogue’ between internal, external microbiota
- Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling
- Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis