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Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

by Igen BioLab Group | Jul 19, 2021 | News, Publications

Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. Insights into biomarkers and mechanisms of response and toxicity to CICB...
A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects

A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects

by Igen BioLab Group | Jul 14, 2021 | News, Publications

Administration of cultured gut isolates holds promise for modulating the altered composition and function of the microbiota in older subjects, and for promoting their health. From among 692 initial isolates, we selected 100 gut commensal strains (MCC100) based on...
‘Multi-kingdom dialogue’ between internal, external microbiota

‘Multi-kingdom dialogue’ between internal, external microbiota

by Igen BioLab Group | Jul 7, 2021 | News, Publications

The billions of organisms living on body surfaces such as the skin of mammals -collectively called microbiota- communicate with each other and the host immune system in a sophisticated network. According to the study, viruses integrated in the host genome, remnants of...
Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling

Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling

by Igen BioLab Group | Jun 21, 2021 | News, Publications

Excessive intake of animal fat and resultant obesity are major risk factors for prostate cancer (PCa). Because the composition of the gut microbiota is known to change with dietary composition and body type, we used prostate-specific Pten knockout mice as a PCa model...
Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis

Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis

by Igen BioLab Group | Jun 14, 2021 | News, Publications

Obesity and poor diet often go hand-in-hand, altering metabolic signaling and thereby impacting breast cancer risk and outcomes. We have recently demonstrated that dietary patterns modulate mammary microbiota populations. An important and largely open question is...
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Recent Posts

  • Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
  • A synthetic consortium of 100 gut commensals modulates the composition and function in a colon model of the microbiome of elderly subjects
  • ‘Multi-kingdom dialogue’ between internal, external microbiota
  • Gut microbiota-derived short-chain fatty acids promote prostate cancer growth via IGF-1 signaling
  • Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis
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